Hydroxysafflor yellow A attenuates the expression of inflammatory cytokines in acute soft tissue injury.
RatCrushLimb / muscle crushWistarMalen = 84 rats randomised into seven groupsIntraperitoneal16, 32 or 64 mg/kgFirst dose 30 min after the strike
Model: Strike-induced acute soft tissue injury of the medial thigh using a 267 g stainless steel hammer with 0.5 cm bottom-surface radius dropped from 30 cm
Hydroxysafflor yellow A dose-dependently reduced oedema, bleeding and inflammatory cell infiltration, lowered plasma IL-6, IL-1beta and TNF-alpha, reduced muscle IL-6, IL-1beta, TNF-alpha, VCAM-1 and ICAM-1 mRNA, and decreased p38 MAPK phosphorylation and the proportion of NF-kappaB p65-positive ce…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.