A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injury repair.
RatSpinal cord injuryComplete transectionSprague-DawleyImplantation into the spinal cord lesionAt the time of injury (acute transplantation)
Model: Acute spinal cord injury with transection gap, scaffold transplanted into the lesion
The CBD-Fab modified linearly ordered collagen scaffold promoted neuronal differentiation and neurite outgrowth under myelin in vitro and, after transplantation into acute rat spinal cord injury, supported neurogenesis of endogenous injury-activated neural stem cells that matured into functional ne…
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