Single Administration of a Sustained-Release Formulation of KB-R7785 Inhibits Tympanic Membrane Regeneration in an Animal Model.
MouseOtherCBAMalen = 20 mice, 40 perforationsLocal application to the tympanic membrane perforation within a polymer hydrogelSingle administration at the time of perforation
Model: Bilateral acute tympanic membrane perforation
A single sustained-release administration kept perforations open in 90% (36/40) at 3 months and 75% (30/40) at 6 months, falling to 22.5% (6/40) at 9 months. Inhibition of healing was the intended therapeutic aim, as an alternative to pressure equalisation tubes, so the direction of effect is coded…
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