Development of Orally Administered gamma-Tocotrienol (GT3) Nanoemulsion for Radioprotection.
MouseRadiationCD2F1Malen = 16 per group (groups of 4) in the radioprotection study; n…Oral gavage, bolus dose of 0.2 mL300 mg/kg GT3 as nanoemulsion for the radioprotection study…24 hours before total body irradiation
Model: Total body irradiation with cobalt-60 gamma rays at an estimated LD70/30 dose (9.0 Gy) delivered at 0.6 Gy/min
Thirty-day survival was 68.75% with GT3 nanoemulsion at 300 mg/kg compared with 43.75% and 50.0% for unformulated GT3 at 200 and 400 mg/kg and 31.25% for blank nanoemulsion. A single oral dose of 600 mg/kg produced no observable toxicity over 14 days, with unchanged body weight, blood counts and no…
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