Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.

Model: Photochemical injury of the common carotid artery producing arterial thrombosis; complementary in vitro work used human aortic endothelial cells stimulated with tumour necrosis factor-alpha

Ticagrelor prolonged time to arterial occlusion compared with clopidogrel despite comparable antiplatelet effects, and reduced tissue factor expression in the endothelium of murine arteries. In human aortic endothelial cells ticagrelor, but not clopidogrel active metabolite, reduced TNF-alpha-induc…

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