Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia.
MouseHaemorrhage/shockUnspecifiedMaleOptimal dose 5 mg/kg; a dose-dependent range was tested
Model: Collagenase-induced intracerebral haemorrhage; in vitro work used lipopolysaccharide-stimulated BV-2 cells and primary microglia
Pinocembrin dose-dependently reduced lesion volume by approximately 47.5% and reduced neurological deficits at 72 hours after collagenase-induced intracerebral haemorrhage. The optimal dose of 5 mg/kg suppressed microglial activation, reduced CD68-positive microglia and proinflammatory cytokines, a…
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