Adenovirus-mediated Foxp3 expression in lung epithelial cells ameliorates acute radiation-induced pneumonitis in mice.
MouseRadiationC57BL/6FemaleIntratracheal injectionAfter irradiation
Model: Focal X-ray irradiation of the lung producing radiation-induced pneumonitis; radiation dose not stated in the abstract
Foxp3 gene delivery significantly inhibited infiltration of eosinophils, lymphocytes, macrophages and neutrophils into bronchoalveolar lavage fluid, reduced inflammatory cell recruitment and collagen deposition on histology, and decreased expression of inflammatory and fibrosis-related genes.
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