Nilotinib, a tyrosine kinase inhibitor exhibits protection against acute pancreatitis-induced lung and liver damage in rats.
RatChemical/toxinSprague-DawleyMale
Model: Acute pancreatitis induced with L-arginine, with secondary lung and liver injury
Acute pancreatitis produced marked deterioration in serum enzymes, nitric oxide, total protein and transforming growth factor beta1, raised tissue lipid peroxidation, reduced superoxide dismutase and glutathione, and caused oedema, haemorrhage, perivascular inflammation and acinar cell necrosis wit…
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