The effects of pprI gene of Deinococcus radiodurans R1 on acute radiation injury of mice exposed to 60Co gamma-ray radiation.
MouseRadiationBALB/cMalen = 120 mice: non-irradiated control n = 5, irradiation with no…Intramuscular injection into femoral muscle with in vivo electroporation60 micrograms of plasmid in 60 microlitres, followed by 8 e…24 h before irradiation
Model: Total body irradiation with 60Co gamma rays, absorbed dose 6 Gy at a dose rate of 2 Gy/min; a preliminary 8 Gy dose killed all mice
PprI protein was detectable at day 1 after irradiation but not at days 7 to 35. After 6 Gy, mortality was 10% in the pprI group versus 50% with irradiation alone and 20% with empty vector (log-rank p < 0.05 versus irradiation alone). White cell counts and the lymphocyte to white cell ratio were sig…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.