Histologic changes of mesenchymal stem cell repair of tympanic membrane perforation.
MouseWoundC57BL/6n = 4 ears per group, three groupsLocal application of cells within a hyaluronic acid scaffold to the perforationSix to eight hours after injury
Model: Bilateral sub-total pars tensa tympanic membrane perforations of equal size made with a sterile 27-gauge needle under a surgical microscope
Untreated perforations developed a hyper-cellular infiltrate around the injury site, whereas treated eardrums showed a reduced inflammatory response at one week and restoration of the trilaminar configuration at two weeks.
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