Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush.
MouseCrushPeripheral-nerve crushC57BL/6 and CXCR3 knockout (from MeSH indexing)Male (from MeSH indexing)
Model: Optic nerve crush producing traumatic optic neuropathy
Deleting CXCR3 in leukocytes reduced leukocyte recruitment and prevented retinal ganglion cell death at 7 days, and a CXCR3 antagonist attenuated injury-induced retinal ganglion cell dysfunction and loss.
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