Potassium Aspartate Attenuates Brain Injury Induced by Controlled Cortical Impact in Rats Through Increasing Adenosine Triphosphate (ATP) Levels, Na+/K+-ATPase Activity and Reducing Brain Edema.
RatTBIControlled cortical impactSprague-Dawley, specific pathogen freeMaleIntraperitoneal, volume 1 mL/kg10, 25, 62.5 and 125 mg/kg30 minutes after controlled cortical impact
Model: Controlled cortical impact under chloral hydrate anaesthesia with craniotomy of about 2.5 mm radius, PinPoint PCI3000 impactor at 1.5 m/s, depth 2.0 mm, dwell 85 ms
Potassium aspartate at 62.5 and 125 mg/kg improved neurological deficits and reduced cortical lesion volume, and 125 mg/kg attenuated brain oedema and blood-brain barrier disruption while raising ATP and Na+/K+-ATPase activity and lowering lactate.
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