Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F-neuroprostane protects the heart against reperfusion injury.
RatIschaemia-reperfusionCardiacIntra-cardiac infusion0.03 mg/kgPrior to coronary occlusion
Model: Myocardial ischaemia-reperfusion by coronary occlusion followed by reperfusion
Intra-cardiac 4-F4t-neuroprostane decreased infarct size by 27% and ventricular arrhythmia score by 41%, reduced post-reperfusion QT lengthening, limited mitochondrial swelling and lowered cytochrome c release and caspase 3 activity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.