Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury.
MouseEndotoxin/LPSMaleOral, as drinking waterPre-administration for 3 days before lipopolysaccharide injection
Model: Lipopolysaccharide-induced endotoxin shock and sepsis with acute liver injury
Drinking hydrogen-rich water for 3 days before lipopolysaccharide prolonged survival and reduced hepatic apoptosis and oxidative stress, with increased haem oxygenase-1 and reduced endothelin-1 expression.
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