Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.
MouseFractureTibiaC57BL/6JMalen = 6 mice per group across 10 groupsInjection; route not specified in the textPHA 568487 0.8 mg/kg and methyllycaconitine 6 mg/kg, dilute…On days 1 and 2 after occlusion, with tibia fracture on day 1
Model: Permanent distal middle cerebral artery occlusion by electrocoagulation through a 2.0 mm burr hole, followed 24 hours later by an open right hind limb tibia fracture with intramedullary fixation
PHA 568487 reduced ipsilateral brain water content in stroke (83.0 to 81.5%, p = 0.023) and stroke with fracture (84.4 to 82.2%, p < 0.001) and reduced monoamine oxidase B positive astrocytes, whereas methyllycaconitine had the opposite effect.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.