Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model.
RatChemical/toxinWistarMalen = Five groups of six animals each, 30 in total; acute toxicit…Oral gavage; toxicant intraperitoneal150 and 300 mg/kg; silymarin comparator 50 mg/kg orally in…Prophylactic pre-treatment for 14 days before injury induction on day 15
Model: Fulminant hepatic failure induced by D-galactosamine 400 mg/kg with lipopolysaccharide 30 micrograms/kg intraperitoneally on day 15, with sampling 24 hours later
Pre-treatment dose-dependently lowered liver enzymes, lipid peroxidation, myeloperoxidase, NF-kappaB activity and pro-inflammatory and apoptotic markers while raising antioxidant enzymes, IL-10 and Bcl-2, with histology comparable to silymarin.
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