PRECLINICAL PUBLICATION · 2016

TNFalpha-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

TNFalpha-stimulated gene-6 (TSG6), a secreted 30 kDa immunomodulatory protein

PMID 27911817 ↗2016Reported benefit

TNFalpha-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

MouseEndotoxin/LPSTSG6 deficient and wild type; MeSH indexing lists BALB/c and C57BL/6Intratracheal instillation

Model: Lipopolysaccharide-induced inflammatory lung injury

TSG6 deficient mice showed markedly augmented lipopolysaccharide-induced lung injury and mortality, and intratracheal TSG6 prevented lung injury and neutrophil sequestration and increased survival.

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