The change of HCN1/HCN2 mRNA expression in peripheral nerve after chronic constriction injury induced neuropathy followed by pulsed electromagnetic field therapy.
RatCrushPeripheral-nerve crushSprague-DawleyMalen = Three groups with 11 rats each, 33 in totalWhole-body exposure with the rat in a plastic cage placed in the therapeutic area of the machine3.8 mT, 8 Hz, 30 minutes per sessionTreatment began on the first day after surgery
Model: Chronic constriction injury of the left sciatic nerve after Bennett and Xie, with four loose 4-0 chromic gut ligatures at 1 mm spacing at mid-thigh under sodium pentobarbital anaesthesia
Pulsed electromagnetic field therapy prolonged paw withdrawal latency and raised withdrawal threshold versus injury alone from day 7 to day 14 and restored dorsal root ganglion Nissl bodies, but did not reverse the injury-induced fall in HCN1 and HCN2 mRNA.
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