Acute or Delayed Treatment with Anatabine Improves Spatial Memory and Reduces Pathological Sequelae at Late Time-Points after Repetitive Mild Traumatic Brain Injury.
MouseTBIClosed-head / concussionC57BL/6 (per indexing terms)Male (per indexing terms)Oral, delivered continuously in drinking waterTreatment started 30 min after injury; a delayed arm was created by crossover a…
Model: Repetitive mild traumatic brain injury: five midline impacts at 5 m/s, 1 mm strike depth, 200 ms dwell time, at 48 h intervals
Both early and delayed anatabine treatment improved spatial memory and reduced astroglial and microglial responses at late time points after repetitive mild traumatic brain injury.
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