Pharmacodynamic evaluation of Lys, MeLeu, Nle-NKA prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats.
RatSpinal cord injuryComplete transectionSprague-DawleyFemalen = 67 rats in total; 4 to 16 per dose group for bladder studie…Intravenous, followed by a 0.3 mL saline flush0.01 to 300 microgram/kg for isovolumetric cystometry, 0.1…Dosing began approximately 1 h after acute spinal cord transection
Model: Complete spinal cord transection at T9 to T10 following laminectomy, performed 1 h before study, under urethane anaesthesia; spinally intact rats used in parallel
LMN-NKA produced rapid onset (under 60 s) and short duration (under 15 min) dose dependent bladder contractions. Intact rats voided at doses above 0.3 to 1 microgram/kg with about 70 per cent efficiency, while spinalised rats required at least 10 microgram/kg and achieved 30 to 50 per cent efficien…
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