Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats.
RatChemical/toxinWistarMalen = 64 male Wistar rats allocated to four groupsIntraperitonealPamidronate 3 mg/kg intraperitoneally; doxorubicin 20 mg/kg…Pamidronate given 24 h before doxorubicin; animals killed 48 h after doxorubicin
Model: Acute doxorubicin-induced cardiotoxicity, single doxorubicin injection 20 mg/kg intraperitoneally
Pamidronate attenuated oxidative stress and improved myocardial energetic metabolism but worsened systolic function, with lower left ventricular ejection fraction and lower +dP/dt in the doxorubicin plus pamidronate group, alongside serum hypocalcaemia. The authors do not recommend its use with ant…
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