Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through alpha7nAChR-dependent JAK2-STAT3 signaling.
MixedCrushLimb / muscle crushSprague-Dawley rats; C57BL/6 mice; B6.129S7-Chrna7tm1Bay alpha7nAChR knockout mice; rabbit strain not statedn = Rats: n = 15 per group for survival dose finding, n = 20 pe…IntraperitonealRats: anisodamine 0, 5, 10 or 20 mg/kg with neostigmine 0,…Optimal administration 30 min before decompression; comparison arms dosed immed…
Model: Acute lethal crush syndrome by hind-limb compression under anaesthesia: rats 20 kg block for 5 h, mice 20 kg block for 4 h, rabbits 40 kg block for 6 h, followed by decompression
The combination raised 24 h survival from 13.3 per cent to 86.7 per cent in rats (20 mg/kg plus 40 microgram/kg given 30 min before decompression), from 37.5 per cent to 87.5 per cent in rabbits, and from 30.8 per cent to 69.2 per cent in wild-type mice. It improved mean arterial and systolic blood…
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