Epidermal growth factor in the gastroprotective and ulcer-healing actions of sucralfate in rats.
RatChemical/toxinMaleOral (epidermal growth factor given orally in restoration experiments)Before ethanol challenge for protection and after ulcer induction for healing
Model: Ethanol-induced gastric mucosal damage and chronic gastric and duodenal ulceration induced by serosal acetic acid
Sucralfate protected the gastric mucosa against ethanol damage and increased mucosal prostaglandin generation independently of endogenous epidermal growth factor, and enhanced healing of acetic acid ulcers. Ulcer healing was reduced by sialoadenectomy and partially restored by oral epidermal growth…
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