alpha-Adrenergic Receptor Antagonism Improves Erectile and Cavernosal Responses in Rats With Cavernous Nerve Injury and Enhances Neurogenic Responses in Human Corpus Cavernosum From Patients With Erectile Dysfunction Secondary to Radical Prostatectomy.
RatCrushPeripheral-nerve crushSprague-DawleymaleOral (long-term); intravenous (acute); ex vivo bath applicationPhentolamine 1 mg/kg daily; silodosin 0.1 mg/kg daily (long…Treatment started after bilateral crush cavernous nerve injury
Model: Bilateral cavernous nerve crush injury (BCNI)
Long-term silodosin improved erectile responses, partly restored nitrergic relaxation, normalised neurogenic contractions and partly prevented the injury-induced fall in neuronal nitric oxide synthase expression. Acute silodosin also improved erectile responses and potentiated tadalafil. In human t…
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