4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.
MouseCrushPeripheral-nerve crushC57BL/6Femalen = Minimum of 5 and generally 8 mice per group, experiments re…Intraperitoneal for systemic dosing; local implantation of 4-AP-PLGA carriers in PEG hydrogel at the crush site10 ug per day systemically; local PLGA microparticles conta…First dose 24 h after injury
Model: Sciatic nerve crush injury (30 s crush); nerve transection and sham surgery also used
Daily 4-aminopyridine started 24 h after sciatic crush accelerated gait recovery, improved nerve conduction velocity and increased remyelination and axonal area without worsening neuropathic pain.
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