Human CD133Renal Progenitor Cells Induce Erythropoietin Production and Limit Fibrosis After Acute Tubular Injury.
MouseChemical/toxinSCIDMalen = n = 10 per group for PBS and CD133+ cells, n = 3 per group…Intravenous, tail vein500,000 cells in 150 uLOne day after injury
Model: Glycerol-induced rhabdomyolysis acute kidney injury, 50 percent hypertonic glycerol injected intramuscularly, half dose into each hind leg
A single intravenous dose of human CD133+ renal progenitor cells one day after glycerol-induced AKI limited fibrosis to day 60, restored peritubular capillaries, reduced anaemia and raised renal and circulating erythropoietin, while dermal fibroblasts and PBS had no effect.
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