Transport patterns of anti-TNF-alpha in burn wounds: Therapeutic implications of hyaluronic acid conjugation.
RatBurnUnspecifiedSprague-DawleyDistribution assessed up to 24 hours after burn injury
Model: Deep partial-thickness thermal burn
Hyaluronic acid conjugation significantly increased antibody residence time in the superficial region of the burn at 24 hours, which correlated strongly with the pattern of inflammatory cell infiltrate. The study characterised transport and biodistribution rather than injury outcome, so a therapeut…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.