Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties.
MouseChemical/toxinBALB/cNFemalen = n = 10 per group in the survival study; n not stated for ot…Intravenous, tail vein1,000 mg Hb/kg24 h after the start of CDE diet feeding
Model: Choline-deficient ethionine-supplemented diet induced severe acute pancreatitis with secondary distal organ injury; 24 h fast then CDE diet for 3 days for efficacy studies or 5 days for the 14-day mortality study
A single intravenous dose of CO-HbV improved 14-day survival and reduced pancreatic enzyme release, systemic cytokines, neutrophil infiltration and oxidative injury in pancreas, liver, kidney and lung, whereas oxygen-bound HbV was ineffective.
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