Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.
MouseOtherC57BL/6J, plus Nampt transgenic and Nampt floxed lines on C57BL/6 backgroundmaleOral, in drinking water3.0 mg/ml in drinking water, approximately 500 mg/kgStarted 14 days before partial hepatectomy in wild-type experiments; in the Nam…
Model: Two-thirds partial hepatectomy (resection of median and left lateral lobes)
Nicotinamide riboside raised hepatic NAD by about 22 per cent before and 42 per cent at 48 h after hepatectomy, increased DNA synthesis, raised mitotic activity by 48 per cent, improved liver mass restoration and accelerated ATP recovery, while nearly abolishing regeneration-associated steatosis. H…
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