Manganese Superoxide Dismutase Gene-Modified Mesenchymal Stem Cells Attenuate Acute Radiation-Induced Lung Injury.
MouseRadiationNonobese diabetic/severe combined immunodeficiency (NOD/SCID)maleIntravenous transfusionAfter whole-thorax irradiation, with monitoring for 30 days
Model: Whole-thorax irradiation with a 13 Gy dose
Systemic administration of MnSOD gene-modified mesenchymal stem cells attenuated lung inflammation, reduced lung damage and protected lung cells from apoptosis, with the cells differentiating into epithelial-like cells in vivo.
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