Oral administration of a recombinant cholera toxin B subunit promotes mucosal healing in the colon.
MouseChemical/toxinC57BL/6femaleOral
Model: Dextran sodium sulfate induced acute colitis, plus an azoxymethane/dextran sodium sulfate colitis-associated cancer model
Oral CTBp protected against colonic mucosal damage with reduced body weight loss, lower histopathological scores and blunted inflammatory cytokine escalation, induced wound healing genes, and reduced disease severity and tumourigenesis in the azoxymethane/dextran sodium sulfate model.
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