Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury.
RatHaemorrhage/shockControlledLewismalen = 50 rats entered the shock model plus 10 sham and 32 donor r…Intravenous, via femoral vein catheterSuspension at haemoglobin 10 g/dL and lipids 8 g/dL; infuse…After 60 minutes of hypotension and after Ringer's lactate infusion given over…
Model: Traumatic haemorrhagic shock, 5 cm midline laparotomy followed by withdrawal of 40 per cent of total blood volume over 10 minutes and maintenance of mean arterial pressure below 40 mmHg for 60 minutes
Six-hour survival was 90.9 per cent with haemoglobin vesicles, 83.3 per cent with fresh packed red blood cells and 76.9 per cent with 28-day-stored packed red blood cells, with no significant difference between groups. Haemodynamic and blood gas recovery with haemoglobin vesicles matched fresh pack…
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