Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.
MouseHaemorrhage/shockUnspecifiedC57BL/6J wild-typemale
Model: subarachnoid haemorrhage induced by endovascular perforation
ApoE-mimetic peptide treatment reduced BBB permeability, tight junction degradation and endothelial and neuronal apoptosis, reduced brain oedema, increased cerebral glucose uptake and improved neurological function after experimental SAH in mice, associated with inhibition of proinflammatory MMP-9…
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