A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity.
RatOtherSprague-Dawleymale
Model: aldosterone and salt-induced kidney injury in rats, with corroborating in vitro studies in rat renal fibroblast cells
Camostat mesilate inhibited plasmin protease activity and suppressed plasmin-induced pro-fibrotic and inflammatory gene expression in renal fibroblasts, and ameliorated glomerulosclerosis and interstitial fibrosis in aldosterone and salt-treated rat kidneys.
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