Human endometrial regenerative cells alleviate carbon tetrachloride-induced acute liver injury in mice.
MouseChemical/toxinC57BL/6malen = n=6 per group, 3 groups, 18 mice totalintravenous1 x 10^6 cells per mouse in 200 microlitres PBS30 minutes after CCl4 injection
Model: carbon tetrachloride (CCl4)-induced acute liver injury
ERC treatment decreased CCl4-induced elevation of serum ALT and AST, improved liver histopathology, increased hepatocyte proliferation, reduced neutrophil infiltration, reduced pro-inflammatory cytokines while increasing IL-10, reduced splenic CD4+ and CD8+ T cells and dendritic cell MHC-II express…
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