Diadenosine tetraphosphate (Ap4A) inhibits ATP-induced excitotoxicity: a neuroprotective strategy for traumatic spinal cord injury treatment.
MouseSpinal cord injuryContusionintraspinal administration in vivo; in vitro experiments in Neuro2a cellsacute administration following SCI, exact time point not specified in available…
Model: moderate contusive spinal cord injury
Ap4A reduced ATP-dependent excitotoxic death in Neuro2a cells by lowering intracellular calcium responses and purinergic receptor expression, and acute administration after contusive SCI in mice reduced tissue damage and improved motor function recovery.
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