Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition.

Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition.

Model: triptolide-induced acute cardiac injury in mice, with corroborating in vitro studies in triptolide-treated H9c2 cardiomyoblasts

Pharmacological inhibition of GSK-3beta with SB 216763 ameliorated triptolide-induced acute cardiac injury in mice and improved cell viability and reduced apoptosis in triptolide-treated H9c2 cells, via prevention of GSK-3beta-mediated cyclophilin F phosphorylation and desensitisation of the mitoch…

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