Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury.
RatSpinal cord injuryContusionSprague-DawleyMalenorBNI 0, 0.02, 0.08 or 0.32 micromol, followed by morphine…24 hours after contusion, after baseline locomotor and nociceptive assessment
Model: Moderate spinal contusion at T12
The protective effect of norBNI was dose dependent. High doses blocked the adverse effect of morphine on locomotor recovery but markedly reduced analgesia, while low doses preserved analgesia but not recovery. An intermediate dose protected recovery while retaining analgesic efficacy, indicating th…
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