Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration.
RatFractureFemurWistarmalelocal implantation into femoral bone defectimplanted at the time of bone defect creation
Model: femoral bone defect in rat
Fibrinogen 3D scaffolds implanted into rat femoral bone defects led to early granulation tissue infiltration by day 6 followed by defect closure including periosteum repair by 8 weeks, with increased local IL-6 and IL-8 and systemic immune cell shifts at 6 days, and decreased plasma IL-1beta with i…
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