TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner.
RatIschaemia-reperfusionCardiacInjection into the infarct scar and border zoneIn vitro, dose-dependent protection at 50 ng/mL and above.…Immediately after induction of ischaemia (preconditioning)
Model: Myocardial ischaemia and reperfusion by ligation of the left anterior descending coronary artery for 50 minutes followed by reperfusion; hypoxia and reoxygenation in H9C2 cells
TWEAK reduced cardiomyocyte apoptosis in a dose-dependent manner in vitro. In rats, TWEAK preconditioning significantly improved cardiac function and reduced infarct size 21 days after reperfusion, with activation of PI3K/AKT signalling.
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