Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks.
MouseIschaemia-reperfusionRenalNOD/ShiLtSz-scid (NOD-SCID)Intravenous (tail vein)After injury; exact interval not stated
Model: Bilateral renal ischaemia/reperfusion injury (30 min clamp) and a two-stage nephron mass reduction (hyperperfusion) model
RAPC engrafted more than mesenchymal stem cells (2.72-fold at 5 days and 4.16-fold at 10 days), increased patent peritubular capillary density, lowered serum creatinine after ischaemia/reperfusion and improved renal perfusion on MRI; after nephron mass reduction only RAPC produced a persistent redu…
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