Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.
MouseEndotoxin/LPSICRMaleIntravenousFirst dose given just before caecal ligation and puncture
Model: Three models of acute respiratory distress syndrome and ventilator-induced lung injury: caecal ligation and puncture, lipopolysaccharide administration, and mechanical ventilation
Intravenous PC-SOD increased survival and decreased vascular permeability after caecal ligation and puncture, and suppressed vascular permeability, oedema, tissue injury and inflammation after LPS and after mechanical ventilation. Unlike dexamethasone and sivelestat, PC-SOD also suppressed kidney i…
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