Intermittent treatment with haloperidol or quetiapine does not disrupt motor and cognitive recovery after experimental brain trauma.
RatTBIControlled cortical impactSprague-Dawley (Harlan)Malen = 70 rats total: 10 per injured group (TBI plus continuous ve…IntraperitonealHaloperidol 0.5 mg/kg; quetiapine 10 mg/kg; vehicle 1.0 mL/…First dose 24 h after controlled cortical impact or sham surgery
Model: Controlled cortical impact (6 mm flat tip, 2.8 mm tissue deformation at 4 m/s, right hemisphere craniectomy)
No overall differences between injured treatment groups on beam balance or beam walk across days 1-5, and all injured groups were impaired relative to sham. On the final beam-walk day the continuous haloperidol group took significantly longer to traverse the beam than all other injured groups. In t…
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