A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity.
RatOtherSprague-Dawleyfemaleintrathecal
Model: modified spared nerve injury, surgical lesion restricted to a single peripheral branch of the sciatic nerve
In a modified spared nerve injury model with roughly 50% incidence of tactile hypersensitivity, RGS4 was specifically upregulated in the lumbar dorsal root ganglia and dorsal horn of rats that developed tactile hypersensitivity. Intrathecal delivery of the RGS4 inhibitor CCG63802 reversed tactile h…
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