Systemic Administration of Connexin43 Mimetic Peptide Improves Functional Recovery after Traumatic Spinal Cord Injury in Adult Rats.
RatSpinal cord injuryContusionSprague-DawleyFemaleIntraperitonealImmediately and at 2 h and 4 h after injury
Model: Mild spinal cord contusion using the Multicentre Animal Spinal Cord Injury Study impactor
Systemic Peptide5 improved hindlimb locomotor function between 3 and 6 weeks, reduced at-level mechanical allodynia at weeks 1 and 6, lowered total and raised phosphorylated Connexin43 at 8 h, and reduced lesion size and glial reactivity while preserving neuronal numbers at 2 and 6 weeks.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.