Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-alpha up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect.
RatOtherSprague-DawleyMalen = Four rats per group per timepoint for Western blotting; beh…Intraperitoneal10 mg/kgStarting immediately after ligature placement on the day of injury
Model: Chronic constriction injury of the left common sciatic nerve with four loose 4/0 chromic silk ligatures at mid-thigh
Repeated SNC80 attenuated chronic constriction injury-induced mechanical allodynia at days 3 and 7 and reduced then completely blocked ipsilateral sciatic nerve TNF-alpha upregulation, with both allodynia and TNF-alpha elevation returning by day 14 after treatment withdrawal.
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