Inhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: Interference with mTOR and autophagy

Inhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: Interference with mTOR and autophagy

Model: Permanent middle cerebral artery occlusion (pMCAO), permanent focal cerebral ischaemia

Compound C reduced p-AMPK, LC3 and Beclin-1, raised p-mTOR, and significantly reduced neurological deficits, infarct area and brain water content 24 hours after occlusion.

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