Activation of the niacin receptor HCA2 reduces demyelination and neurofilament loss, and promotes functional recovery after spinal cord injury in mice.
MouseSpinal cord injuryUnspecifiedC57BL/6male100 mg/kg in vivo; 300 micromolar in vitrotreatment given after SCI, mice assessed a week after SCI; precise timing of fi…
Model: spinal cord injury in mice, with in vitro M1 macrophage and oligodendrocyte precursor cell co-cultures
Niacin activation of the HCA2 receptor shifted macrophages from an M1 to M2 phenotype, promoted oligodendrocyte myelin binding protein expression, reduced demyelination and neurofilament loss, and improved locomotor recovery after spinal cord injury in mice.
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