Dihydroxyselenolane (DHS) supplementation improves survival following whole-body irradiation (WBI) by suppressing tissue-specific inflammatory responses.
MouseRadiationBALB/cMaleIntraperitoneal2 mg/kgFive consecutive days before irradiation and continuing after irradiation
Model: Whole-body cobalt-60 gamma irradiation, 8 Gy at 1 Gy/min
DHS improved 30-day post-irradiation survival by 40% and reduced leukocyte DNA damage and inflammatory responses in intestine, lung and circulation, although it did not protect against acute 10-day haematopoietic or gastrointestinal toxicity. Selenomethionine gave comparable radioprotection.
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