Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
MouseChemical/toxinIntraperitoneal injection1 to 3 mg/kg
Model: Acetaminophen-induced acute liver injury, plus chronic liver injury models, intestinal injury and the Fah-deficient mouse model of human hepatocyte repopulation
XMU-MP-1 blocked MST1/2 kinase activity, activated Yes-associated protein and augmented mouse intestinal repair and liver repair and regeneration in both acute and chronic liver injury models at 1 to 3 mg/kg intraperitoneally. It also produced substantially greater human hepatocyte repopulation in…
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